Keppel was born Alice Frederica Edmonstone, to William and Mary Elizabeth Edmonstone, née Parsons, at Duntreath Castle in the Blane Valley, near the village of Strathblane, north of Glasgow, the scion of a distinguished family. Her father was the 4th Baronet Edmonstone and a retired Admiral in the Royal Navy; her grandfather had been Governor of the Ionian Islands.
The Prince was fifty-six and Alice twenty-nine. She was an accomplished bridge-player, which appealed to him. "She not only had a gift of happiness but she excelled in making others happy," said a contemporary. Queen Alexandra is said to have preferred the discreet Mrs. Keppel to the Prince's previous mistress. In 1910, when Edward VII was dying and asked for Alice's presence, Queen Alexandra allowed her to be present.
Her full title after marriage was The Hon. Mrs George Keppel. Her daughter, Violet Trefusis, was the lover of poet Vita Sackville-West.
She is the matrilineal great-grandmother of Camilla, Duchess of Cornwall, second wife of Charles, Prince of Wales.
It is worth noting that in a series of ten greetings stamps Great Britain issued in 1995 a remarkable -- yet unnoticed -- stamp, showing Mrs. Keppel with her daughter, Violet Trefusis.